Prednisolone Acetate
Crystalline injectable suspension for systemic and local therapy in acetonemia and inflammatory conditions.
Composition :
Each ml contains: Prednisolone acetate I.P. 10 mg
Indications :
Prednisolone is indicated in ketosis in diary cattle, shock, inflammations (especially rheumatic arthritis, dermatitis, bursitis) and allergic conditions of livestock.
Mechanism of action
- Improves the blood glucose level, which is the most desired proposition in ketosis and shock.
- Stabilizes vascularity of epithelial membranes.
- Potent anti-inflammatory and anti-histaminic activity by inhibition of prostaglandins.
- Marginal mineralocorticoid activity reduces the risk of excessive drainage of minerals from the body as observed after treatment of other potent cortizones.
Administration and dosage :
Prednisolone crystaline suspension is injected deep intramuscularly for systemic treatment. It may be repeated 2-4 times if necessary, at intervals of 24 hours, along with suitable chemotherapeutic agents
For local treatment, Prednisolone crystaline suspension is injected into or around a joint, into the bursa or synovial sheath, beneath the conjunctiva or behind the eyeball, under strict aseptic conditions.
Systemic treatment : (as recommended by Veterinarian)
Cattle, horses : 5 - 20 ml
Calves, pigs : 2.5 - 5 ml
Piglets, dogs, cats : 1 - 3 ml.
Injection into joints or tendon sheaths :
Large animals : Varying according to the size of the joint or tendon sheaths 2.5-7.5 ml or more
Dogs and cats : 0.5 – 2 ml.
Injection into bursae : 1-5 ml or more according to the extent of the disease process.
Subconjunctival injection : 0.125 – 1.25 ml
Retrobulbar injection : 0.125 – 1.25 ml
Infiltration (as in periostitis, etc): 1-5 ml depending upon the extent of the disease condition
Contraindications : It should not be administered more than twice in cases of diabetes mellitus and Osteoporosis
Note :
In order to avoid unnecessary damages to the joint capsules, specially when repeated injections have to be given, the needle should be as fine as possible. After intra-articular injection the joint should be moved a few times to ensure even distribution
of Prednisolone Crystaline Suspension. Excessive load and hard exercise must be avoided during the first eight days after injection.
For special reasons if it is desired to treat a local process by intramuscular injection rather than injection into the affected part, the same dosage should be used, as recommended for the systemic therapy. Withdrawal in tapering doses is
recommended
Presentation :
R. C Vial of 10 ml.
