Nobilis® ND Clone 30

Description :
Live ND virus, strain Clone 30, Iyophilised, with a stabilizer

Indication :
ND vaccine Nobilis Clone 30 has, as a main characteristic, a high immunogenicity paired with a mild reaction. Therefore it is specifically suited to protect chickens relatively susceptible to bacterial and viral stresses

Vaccination programme :
The optimal time schedule and method of administration of ND Vaccine Nobilis Clone 30 depends largely upon the local situation.

• Imminent danger of N.D. infection
• Presence of Mycoplasmas and other agents likely to cause undue vaccination reactions. Therefore the advice of a veterinary surgeon should be sought.

Examples :

• High risk of ND infection
• 1st vaccination by spray at day-old
• 2nd vaccination by knapsack sprayer at 3-4 weeks of age
• Low risk of ND infection

Mycoplasmas present :

• 1st vaccination in the drinking water or by intranasal route at 3 weeks of age.
• 2nd vaccination in the drinking water at 8 weeks of age.

Low risk of undue vaccination reactions :

• Vaccination by knapsack sprayer at 1-2 weeks of age (may be sufficient for broiler flocks)

Administration :

A. Drinking water vaccination :

• The vial should be opened under water
• Mix the vaccine and the water thoroughly with a clean stirrer. When the vaccine is dissolved, it is very vulnerable and will loose its activity within a few hours.

Therefore :

1. Ensure intake of all the vaccine-medicated water in 2 hours.
2. A sufficient number of water containers to provide adequate drinking space is essential and they should be clean and free from any traces of, detergents or disinfectiants. Depending on the climatic condition, it may be advisable to deprive the birds of water prior to vaccination
3. Use cool, non-chlorinated, non-ferruginous tap or rainwater. In equal parts of fresh milk and water, the virus retains its activity much longer.
4. Dissolve 1000 doses in as many litres of water as the age of the birds in days to a maximum of 40 litres.
   The vaccine should be given in the early morning (main period of drinking, coolperiod on a hot day).
5. When vaccinating larger flocks, it is advisable to start by dissolving only part of the vaccine. If the vaccine is administered through a central water supply or a propotioner, great care should be taken.
6. For numbers of birds in between standard dosages, the next higher dosage should be chosen

B. Intranasal instillation :

• The vaccine should be dissolved in normal saline solution, using 30 ml per 1000 doses.

C. Spray vaccination with knapsack spraying apparatus :

• Any knapsack spraying apparatus for agricultural purposes may be used, provided that no traces of disinfecting agents are present (preferably reserve a separate apparatus for vaccination purposes) and that the apparatus is completely free from sediments or corrosion. Best results are obtained with nozzles producing small droplets (Aerosol generators should be used only when this is known to be safe for the birds).
• Dissolve 1000 doses per litre of water of good quality. Spray the vaccine-medicated water evenly over the correct number of chickens (preferably when the birds are sitting together in dim light).

D. Spray vaccination of day-old chicks :

• Keep the chicks in the boxes. Place the boxes closely together in rows. Dissolve 1000 doses per ½ litre of water of good quality. Use a hand sprayer or knapsack sprayer, equipped with a nozzle producing droplets falling like a fine rain.
• Distribute the vaccine-medicated water evenly over the correct number of boxes.

Presentations :
Vials of 1000 and 2500 doses in boxes of 10 vials.